期刊
NATURE NANOTECHNOLOGY
卷 16, 期 9, 页码 1011-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41565-021-00922-3
关键词
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资金
- National Key R&D Program of China [2017YFA0207303]
- National Natural Science Foundation of China (NSFC) [22088101, 51961145403, 21725502]
- Research Program of Science and Technology Commission of Shanghai Municipality [20JC1411700, 19490713100, 20490710600]
- National Natural Science Foundation of China [21904023, 11974097]
This study presents a series of X-ray-activated, lanthanide-doped nanoparticles with extended emission lifetime in the second near-infrared window (NIR-II), providing high-contrast bioimaging in deep tissue. The core-shell engineering enables tunable NIR-II persistent luminescence, outperforming fluorescence and allowing accurate imaging with high contrast.
Persistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core-shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000-1,700 nm). Core-shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (similar to 2-4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence-magnetic resonance-positron emission tomography imaging of murine tumours.
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