期刊
NATURE MEDICINE
卷 27, 期 7, 页码 1230-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-021-01378-7
关键词
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资金
- Fundacao de Amparo a Pesquisa do Estado do Amazonas - FAPEAM
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq [403276/2020-9]
- Inova Fiocruz/Fundacao Oswaldo Cruz [VPPCB-007-FIO-18-2-30-Geracao de conhecimento]
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro - FAPERJ [E-26/202.896/2018]
- CNPq [306146/2017-7, 302317/2017-1]
- Respiratory Viruses Genomic Surveillance Network of the General Laboratory Coordination of the Brazilian Ministry of Health, Brazilian Central Laboratory States
Analysis of circulating SARS-CoV-2 viruses during the first and second waves of COVID-19 in Amazonas, Brazil, shows successive lineage replacements led to predominance of the variant of concern P.1 and are associated with variable levels of social distancing.
The northern state of Amazonas is among the regions in Brazil most heavily affected by the COVID-19 epidemic and has experienced two exponentially growing waves, in early and late 2020. Through a genomic epidemiology study based on 250 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from different Amazonas municipalities sampled between March 2020 and January 2021, we reveal that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195, which was gradually replaced by lineage B.1.1.28 between May and June 2020. The second wave coincides with the emergence of the variant of concern (VOC) P.1, which evolved from a local B.1.1.28 clade in late November 2020 and replaced the parental lineage in <2 months. Our findings support the conclusion that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1 virus. These data provide insights to understanding the mechanisms underlying the COVID-19 epidemic waves and the risk of dissemination of SARS-CoV-2 VOC P.1 in Brazil and, potentially, worldwide. Analysis of circulating SARS-CoV-2 viruses during the first and second waves of COVID-19 in Amazonas, Brazil, shows successive lineage replacements led to predominance of the variant of concern P.1 and are associated with variable levels of social distancing.
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