期刊
NATURE CHEMISTRY
卷 13, 期 11, 页码 1038-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41557-021-00772-5
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资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [364653263-TRR 235 (CRC235)]
- Volkswagen Initiative
- Simons Foundation [327125]
- Germany's Excellence Strategy [EXC-2094-390783311]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [802000]
- MaxSynBio consortium - Federal Ministry of Education and Research of Germany
- MaxSynBio consortium - Max Planck Society
- ERC ADV [834225]
- European Research Council
- Center for Nanoscience Munich (CeNS)
- Quantitative Biology Munich
- European Research Council (ERC) [802000, 834225] Funding Source: European Research Council (ERC)
This study demonstrates how selective magnesium up-concentration by heat flow across rock fissures can rescue ribozyme catalysis inhibited by high-sodium, low-magnesium solutions derived from leaching basalt, providing insights relevant to various origin-of-life scenarios.
Catalytic nucleic acids, such as ribozymes, are central to a variety of origin-of-life scenarios. Typically, they require elevated magnesium concentrations for folding and activity, but their function can be inhibited by high concentrations of monovalent salts. Here we show that geologically plausible high-sodium, low-magnesium solutions derived from leaching basalt (rock and remelted glass) inhibit ribozyme catalysis, but that this activity can be rescued by selective magnesium up-concentration by heat flow across rock fissures. In contrast to up-concentration by dehydration or freezing, this system is so far from equilibrium that it can actively alter the Mg:Na salt ratio to an extent that enables key ribozyme activities, such as self-replication and RNA extension, in otherwise challenging solution conditions. The principle demonstrated here is applicable to a broad range of salt concentrations and compositions, and, as such, highly relevant to various origin-of-life scenarios.
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