A stem-cell basis for skeletal ageing

How ageing contributes to bone loss is unclear. In ageing mice, skeletal stem cells lose their ability to generate bone-forming cells called osteoblasts, and instead promote the generation of bone-resorbing cells called osteoclasts.

Automated summary

As aging progresses, skeletal stem cells in mice lose their ability to generate bone-forming cells and instead promote the generation of bone-resorbing cells.