期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 16, 页码 4125-4131出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1976175
关键词
Ganoderma lucidum; anti-cancer; HepG2; A549; p53; apoptosis
资金
- Administration of Traditional Chinese Medicine of Guangdong Province [20211341]
- National Natural Science Foundation of China [81803689]
- Natural Science Foundation of Guangdong Province [2018A030310292]
- YIWEN Talent Project of The Third Affiliated Hospital of Guangzhou Medical University [2021#9]
Ganoderma lucidum, a traditional medicinal fungus in China, has been found to possess a new triterpene compound that shows moderate anti-tumor activities, possibly inducing apoptosis through the p53/caspase-3 pathway.
Ganoderma lucidum (G. lucidum) is a famous medicinal fungus used as a traditional medicine for generations in China. Among bioactivities that G. lucidum possesses, the anti-tumor effect has aroused extensive interests. In this study, one new triterpene (1) was isolated from 90% ethanol extract of the dried fruiting bodies of G. lucidum. Its structure was determined based on the analysis of its spectroscopic data, including 1 D and 2 D NMR and MS spectra. Furthermore, 1 elicited moderate anti-tumor activities (IC50 values of 15.38 +/- 0.34 and 18.61 +/- 0.55 mu M for A549 and HepG2 cells, respectively) compared with cisplatin which was employed as the positive drug with IC50 values of 8.21 +/- 0.17 and 5.36 +/- 0.29 mu M for A549 and HepG2 cells, respectively. The mechanism study by RT-qPCR and western blot analysis suggested that the p53/caspase-3 pathway is involved in the 1-induced apoptosis.
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