Eupatorin 3′-O-glucopyranoside, a trimethoxyflavonoid glucoside from the aerial parts of Salvia mellifera

Salvia mellifera, native to California, Baja California, and Mexico, is a medicinal herb traditionally used to relieve pain, body aches, including chronic pain. A detailed phytochemical investigation of aerial parts of S. mellifera was accomplished to find species-specific markers and to differentiate the closely related, often (un)intentionally substituted with S. apiana. A total of 22 metabolites, including flavonoids (1-14), triterpenoids (15-18), diterpenoids (19-21), and phenylpropanoid (22), were isolated and characterized thoroughly. Among the isolates, eupatorin 3'-O-glucopyranoside (1) was identified as undescribed phytochemical and detailed structure elucidation was achieved through extensive NMR and mass spectral data analysis. [GRAPHICS]

Automated summary

Salvia mellifera, a medicinal herb used traditionally to relieve pain and fatigue, was studied to find species-specific markers and differentiate it from closely related species. A total of 22 metabolites were isolated and characterized.