期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 10, 页码 2542-2546出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1914612
关键词
Kadsura coccinea; Schisandraceae; triterpene; human cancer cells; antiproliferative activity
资金
- National Foundation for Science and Technological Development
- NAFOSTED [104.01-2019.318]
- Hanoi University of Science and Technology [T2020-PC-053]
A series of schiartane C-29 nortriterpenoids with a unique schinortriterpenoid skeleton were identified from stems of Kadsura coccinea, including a new compound kadcoccilactone V. Compound 6 showed potent cytotoxicity against several human cancer cell lines, indicating potential for further research into its anti-cancer properties.
A series of schiartane C-29 nortriterpenoids with 5/5/7/6/5 membered consecutive rings (1-5) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V (1), together with four known ones (2-5) and three known triterpenoids (6-8) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI(50) 1.28 mu M) and NUGC-3 (GI(50) 1.28 mu M), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI(50) values around 2.33 to 2.67 mu M.
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