Garcimckeans A-C, three new xanthones from the stems of Garcinia mckeaniana, and their cytotoxic activity

Three new xanthones, garcimckeans A-C (1-3) were isolated from the methanol extract of the stems of Garcinia mckeaniana (Clusiaceae). Their structures were established by extensive spectroscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds 1-3 displayed weak cytotoxic activity toward KB, Lu, HepG2, and MCF7 cell lines using the MTT assay with IC50 values ranging from 71.03 +/- 2.93 to 90.40 +/- 7.13 mu M compared to that of the positive control compound, ellipticine (IC50: 1.22 +/- 0.10 similar to 2.44 +/- 0.2 mu M).

Automated summary

Three new xanthones were isolated from Garcinia mckeaniana stems, and they exhibited weak cytotoxic activity against several cell lines.