期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 20, 页码 5255-5262出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1929974
关键词
Chloranthus multistachys Pei; sesquiterpene; enantiomer; anti-inflammatory
资金
- National Natural Science Foundation of China [82060697]
- Doctoral Research Initiation Fund of Jiangxi University of Chinese Medicine [2018BSZR003]
Phytochemical investigation on Chloranthus multistachys Pei led to the discovery of three pairs of new sesquiterpene enantiomers, whose structures and configurations were determined by various techniques. However, these compounds did not show anti-inflammatory activity according to the evaluation using the RAW 264.7 macrophage inflammatory model.
Phytochemical investigation on the whole plant of Chloranthus multistachys pei (Chloranthaceae) afforded three pairs of new sesquiterpene enantiomers (+)/(-)-chlorantene M [(+)/(-)-1], (+)/(-)-chlorantene M1 [(+)/(-)-2] and (+)/(-)-chlorantene N [(+)/(-)-3]. The structures of new compounds were determined through spectroscopic techniques (HR-ESI-MS, 1 D and 2 D NMR), besides, their absolute and relative configurations were established by using Single-crystal X-ray diffraction analysis and CD spectrum. The anti-inflammatory potential of all compounds was evaluated by applying LPS induced RAW 264.7 macrophage inflammatory model, and the results were that none of these compounds showed activity (IC50 > 100 mu M).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据