Small Molecule Constituents of Periplaneta americana and Their IL-6 Inhibitory Activities

Two new glycosides, periplanosides A (1) and B (2), 3 compounds reported from a natural source for the first time (3-5), and 6 known compounds 6-11 were isolated from the ethanol extract of Periplaneta americana (Linnaeus). Their structures, including absolute configurations, were unambiguously identified by comprehensive spectroscopic and chemical methods. Compound 3 is a racemate whose enantiomers were purified by chiral high-performance liquid chromatography. The biological evaluation results showed that compound 7 (0 - 20 mu M) did not affect the viability of RAW264.7 cells and could effectively inhibit the production of interleukin-6 stimulated by lipopolysaccharide in a concentration-dependent manner, indicating the potential to develop novel agents against inflammation-related diseases.

Automated summary

Two new glycosides were isolated from the ethanol extract of Periplaneta americana, along with 3 compounds reported from a natural source for the first time. One of the compounds showed potential to develop novel agents against inflammation-related diseases.