期刊
NANOTECHNOLOGY
卷 33, 期 35, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1361-6528/ac18d6
关键词
multidrug resistance; nanostructured lipid carriers; controlled release; combination therapy; paclitaxel
资金
- Natural Science Foundation of Heilongjiang province of China [H2018013]
- Outstanding Young Talents Funding of College of Pharmacy, Harbin Medical University [2019-JQ-03]
- Young Talents Start-up Funding of College of Pharmacy, Harbin Medical University [2019-QD-07]
- fundamental Research funds for the Heilongjiang provincial universities [2019-KYYWF-0397]
This study successfully developed a tunable controlled release lipid platform (PT@usNLC) for coordinated delivery of paclitaxel and tetrandrine, which showed improved therapeutic effects and provided a new strategy for resistant ovarian cancer therapy.
Multidrug resistance has dramatically compromised the effectiveness of paclitaxel (PTX). The combined application of PTX and tetrandrine (TET) is a promising avenue in drug-resistant cancer therapy. However, poor drug release and limited intracellular drug accumulation greatly impede this combinational antitumor therapy. To address this problem, we successfully developed a tunable controlled release lipid platform (PT@usNLC) for coordinated drug delivery. The drug release rate of PT@usNLC can be tuned by varying the lipid ratio, which has potential to maximize the therapeutic effects of combined drugs. The TET release rate from PT@usNLC was faster than PTX, which could restore the sensitivity of tumor cells to PTX and exert a synergistic antitumor effect. The appropriate size of PT@usNLC could effectively increase the intracellular drug accumulation. Both in vitro and in vivo studies revealed that PT@usNLC significantly enhanced the therapeutic effect compared to conventional therapies. This study provides a new strategy for resistant ovarian cancer therapy.
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