Application of lanthanide-doped upconversion nanoparticles for cancer treatment: a review

With the excellent ability to transform near-infrared light to localized visible or UV light, thereby achieving deep tissue penetration, lanthanide ion-doped upconversion nanoparticles (UCNP) have emerged as one of the most striking nanoscale materials for more effective and safer cancer treatment. Up to now, UCNPs combined with photosensitive components have been widely used in the delivery of chemotherapy drugs, photodynamic therapy and photothermal therapy. Applications in these directions are reviewed in this article. We also highlight microenvironmental tumor monitoring and precise targeted therapies. Then we briefly summarize some new trends and the existing challenges for UCNPs. We hope this review can provide new ideas for future cancer treatment based on UCNPs.

Automated summary

UCNP, with the ability to convert near-infrared light to visible or UV light, are promising nanomaterials for effective and safe cancer treatment. They have been widely used in chemotherapy drug delivery, photodynamic therapy, and photothermal therapy. UCNP can also be applied in tumor monitoring and precise targeted therapy.