期刊
NANO TODAY
卷 39, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2021.101196
关键词
Electrospun nanofiber; Electroactive; Tissue engineering
资金
- Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award [113548]
- US METAvivor Early Career Investigator Award [2018A020560]
- Harvard Medical School/Brigham and Women's Hospital Department of Anesthesiology Basic Scientist Grant [2420 BPA075]
- Khoury Innovation Award [2020A003219]
- American Heart Association Collaborative Science Award [2018A004190]
- National Natural Science Foundation of China [52073014, 82002049]
- Key Program of Beijing Natural Science Foundation [Z200025]
Electrospun nanofibers with electroactive properties have shown great potential and prospects in tissue engineering, especially in areas such as heart repair, nerve injury treatment, wound healing, skeletal muscle and bone regeneration. Future research focuses on developing more intelligent, portable, monitorable, and safe scaffolds.
The ability of electrospun nanofibers to mimic the structure and composition of certain components of the extracellular matrix (ECM) has been widely used in the construction of tissue regeneration scaffolds. As the biophysical cues of the ECM, bioelectric communication mediated by endogenous electrical fields and currents also plays an important role in the repair and regeneration of defected tissues. To this end, it is compelling to develop electroactive electrospun nanofibers for tissue engineering. Here, we briefly summarize the commonly developed electroactive electrospun nanofibers and their progress in tissue engineering, especially for heart repair, nerve injury treatment, wound healing, skeletal muscle and bone regeneration. We also discuss their potential applications as biosensors and drug delivery platforms. Afterwards, we specifically focus on the future direction of the design and functionalization of electroactive electrospun nanofibers for tissue engineering. At last, we propose several promising strategies to make the scaffolds more intelligent, portable, monitorable, and safe. (c) 2021 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据