期刊
NANO RESEARCH
卷 15, 期 1, 页码 728-737出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-021-3553-2
关键词
nanodisks; Cys-Arg-Glu-Lys-Ala with N-methylated Glu (CR(NMe)EKA); tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); lung melanoma metastasis; tumor-targeting
类别
资金
- Regional Innovation and Development Joint Fund [U20A20441]
- National Science Fund for Excellent Young Scholars [82022070]
In this study, a novel nanoplatform was developed to deliver TRAIL and PTX to lung melanoma tumor sites, effectively killing tumor cells and reducing local nutrition supply. This system showed remarkable anti-tumor effects and significantly prolonged the survival rate of melanoma lung metastasis bearing mice.
Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung, leading to sharply reduced patients' survival rate. Effectively treating these tumors thus could improve late stage melanoma with lung metastasis. In this study, we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu (CR(NMe)EKA) decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PTX) to lung melanoma tumor sites (TRAIL-[ND-PTX] CR(NMe)EKA). These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles, while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded drugs. The combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply, leading to stronger overall anti-tumor effect. This TRAIL-[ND-PTX]CR(NMe)EKA system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice, without displaying significant toxicity. Hence, this designing strategy and the fabricated nanoplatform possess potential for further development.
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