期刊
NANO LETTERS
卷 21, 期 16, 页码 6914-6922出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c02078
关键词
Ultrahigh sensitive; tumor-specific photoacoustography; optical writing; redox-responsive; AgBr@PLGA nanocrystals
类别
资金
- National Natural Science Foundation of China [61822505, 61805085, 61627827]
- Science and Technology Planning Project of Guangdong Province, China [2015B020233016, 2018A030310519]
- Guangzhou Science and technology plan project [201904010321]
- Science and Technology Program of Guangzhou [2019050001]
An ultrahigh-sensitive and tumor-specific photoacoustography technique using photosensitive silver bromide nanocrystals has been developed for rapid and accurate identification of tumor tissues in the near-infrared region. Experimental results demonstrate that this tumor-specific photoacoustography technology holds great promise for high-precision cancer diagnosis and treatment monitoring.
The highly up-regulated glutathione (GSH) concentration in the tumor microenvironment is generally identified to be an effective endogenous characteristic of cancerous tissues. Herein, an ultrahigh-sensitive and tumor-specific photoacoustography technique in the near-infrared (NIR-II) region based on optical writing and redox-responsive chromogenic graphic fixing is developed by introducing a self-synthesized photosensitive silver bromide modified with poly lactic-co-glycolic acid (AgBr@PLGA) nanocrystals. After they are optically triggered by external light, the NIR-transparent AgBr@PLGA nanocrystals can be reduced by the tumor-abundant GSH into strongly absorbing silver nanoparticles, significantly boosting the turn-on photoacoustic (PA) signal in the NIR-II region; therefore, the tumor area can be graphically fixed and developed in the photoacoustography. Experiments on both in vitro phantoms and in vivo mouse models demonstrate that the tumor area is specifically identified by the photoacoustography with the background signals effectively suppressed by dynamically modulating the exposure time. The tumor-specific photoacoustography technique prefigures great potential for high-precision cancer diagnosis and treatment monitoring.
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