期刊
NANO LETTERS
卷 21, 期 18, 页码 7659-7668出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c02404
关键词
single upconversion nanoparticles; optical fingerprints; multiple dimensions; lifetime profiles
类别
资金
- Australian Research Council Discovery Early Career Researcher Award Scheme [DE180100669]
- China Scholarship Council Scholarships [201508530231, 201706020170, 201607950009]
- Australia-China Joint Research Centre for Point-of-Care Testing [ACSRF65827, 2017YFE0132300]
- Science and Technology Innovation C o m m i s s i o n o f S h e n z h e n [KQTD20170810110913065]
- Science and Technology Innovation Commission of Shenzhen [20200925174735005]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- National Natural Science Foundation of China [61729501]
- Major International (Regional) Joint Research Project of NSFC [51720105015]
The article discusses the resolution of the entire lifetime profile of single upconversion nanoparticles using various microscopy techniques, pushing the limit of optical multiplexing from microscale to nanoscale, and exploring the creation of time-domain optical fingerprints using nanophotonic upconversion schemes.
The control in optical uniformity of single nanoparticles and tuning their diversity in multiple dimensions, dot to dot, holds the key to unlocking nanoscale applications. Here we report that the entire lifetime profile of the single upconversion nanoparticle (tau(2) profile) can be resolved by confocal, wide-field, and super-resolution microscopy techniques. The advances in both spatial and temporal resolutions push the limit of optical multiplexing from microscale to nanoscale. We further demonstrate that the time-domain optical fingerprints can be created by utilizing nanophotonic upconversion schemes, including interfacial energy migration, concentration dependency, energy transfer, and isolation of surface quenchers. We exemplify that three multiple dimensions, including the excitation wavelength, emission color, and tau(2) profile, can be built into the nanoscale derivative tau(2)-dots. Creating a vast library of individually preselectable nanotags opens up a new horizon for diverse applications, spanning from sub-diffraction-limit data storage to high-throughput single-molecule digital assays and super-resolution imaging.
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