期刊
BRITISH JOURNAL OF CANCER
卷 112, 期 9, 页码 1501-1509出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2015.101
关键词
ovarian cancer; interferon-gamma; PD-L1; lymphocyte; peritoneal dissemination; CD8
类别
资金
- MEXT (The Ministry of Education, Culture, Sports, Science and Technology)
- Grants-in-Aid for Scientific Research [26293359, 26670723] Funding Source: KAKEN
Background: PD-L1 (programmed cell death 1 ligand 1) on tumour cells suppresses host immunity through binding to its receptor PD-1 on lymphocytes, and promotes peritoneal dissemination in mouse models of ovarian cancer. However, how PD-L1 expression is regulated in ovarian cancer microenvironment remains unclear. Methods: The number of CD8-positive lymphocytes and PD-L1 expression in tumour cells was assessed in ovarian cancer clinical samples. PD-L1 expression and tumour progression in mouse models under conditions of altering IFN-gamma signals was assessed. Results: The number of CD8-positive cells in cancer stroma was very high in peritoneally disseminated tumours, and was strongly correlated to PD-L1 expression on the tumour cells (P<0.001). In mouse models, depleting IFNGR1 (interferon-gamma receptor 1) resulted in lower level of PD-L1 expression in tumour cells, increased the number of tumour-infiltrating CD8-positive lymphocytes, inhibition of peritoneal disseminated tumour growth and longer survival (P - 0.02). The injection of IFN-gamma into subcutaneous tumours induced PD-L1 expression and promoted tumour growth, and PD-L1 depletion completely abrogated tumour growth caused by IFN-gamma injection (P = 0.01). Conclusions: Interferon-g secreted by CD8-positive lymphocytes upregulates PD-L1 on ovarian cancer cells and promotes tumour growth. The lymphocyte infiltration and the IFN-gamma status may be the key to effective anti-PD-1 or anti-PD-L1 therapy in ovarian cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据