相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。3D gastrointestinal models and organoids to study metabolism in human colon cancer
Catarina Silva-Almeida et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)
Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells
Kerstin Schneeberger et al.
HEPATOLOGY (2020)
Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform
Shiny Amala Priya Rajan et al.
ACTA BIOMATERIALIA (2020)
Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches
Sungjin Min et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)
Stefan Pfuhler et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2020)
Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids
Matthew Devall et al.
PLOS ONE (2020)
Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
Aditya Mithal et al.
NATURE COMMUNICATIONS (2020)
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
Camilla Calandrini et al.
NATURE COMMUNICATIONS (2020)
Organoid models of childhood kidney tumours
Ariadne H. A. G. Ooms et al.
NATURE REVIEWS UROLOGY (2020)
Adaptation of the in vitro micronucleus assay for genotoxicity testing using 3D liver models supporting longer-term exposure durations
Gillian E. Conway et al.
MUTAGENESIS (2020)
Human organoids: model systems for human biology and medicine
Jihoon Kim et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity
Chi Zhang et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)
Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry
Andreas R. Baudy et al.
LAB ON A CHIP (2020)
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
Aleksander Skardal et al.
BIOFABRICATION (2020)
The comet assay applied to HepG2 liver spheroids
Elisabeth Elje et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2019)
Tubuloids derived from human adult kidney and urine for personalized disease modeling
Frans Schutgens et al.
NATURE BIOTECHNOLOGY (2019)
Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
Gitte Berkers et al.
CELL REPORTS (2019)
Stem cell models as an in vitro model for predictive toxicology
Stephen Lynch et al.
BIOCHEMICAL JOURNAL (2019)
Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma
Yoshimasa Saito et al.
CELL REPORTS (2019)
Disease modelling in human organoids
Madeline A. Lancaster et al.
DISEASE MODELS & MECHANISMS (2019)
Organoids are promising tools for species-specific in vitro toxicological studies
Justyna Augustyniak et al.
JOURNAL OF APPLIED TOXICOLOGY (2019)
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
Seon Ju Mun et al.
JOURNAL OF HEPATOLOGY (2019)
Three-dimensional culture of endometrial cells from domestic cats: A new in vitro platform for assessing plastic toxicity
Morgan Dundon et al.
PLOS ONE (2019)
Development of in vitro 3D cell model from hepatocellular carcinoma (HepG2) cell line and its application for genotoxicity testing
Martina Stampar et al.
ARCHIVES OF TOXICOLOGY (2019)
Long-term expanding human airway organoids for disease modeling
Norman Sachs et al.
EMBO JOURNAL (2019)
Generation of hepatobiliary organoids from human induced pluripotent stem cells
Fenfang Wu et al.
JOURNAL OF HEPATOLOGY (2019)
Development of organoid-based drug metabolism model
Enoch Park et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity
Ling Li et al.
JCI INSIGHT (2019)
Next generation organoids for biomedical research and applications
Yan-Ru Lou et al.
BIOTECHNOLOGY ADVANCES (2018)
Human brain organoid-on-a-chip to model prenatal nicotine exposure
Yaqing Wang et al.
LAB ON A CHIP (2018)
A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies
Ume-Kulsoom Shah et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2018)
Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility
Kerstin Reisinger et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2018)
Cadmium Exposure Inhibits Branching Morphogenesis and Causes Alterations Consistent With HIF-1 alpha Inhibition in Human Primary Breast Organoids
Sabrina A. Rocco et al.
TOXICOLOGICAL SCIENCES (2018)
Morphological alterations of cultured human colorectal matched tumour and healthy organoids
Seyed Mohammad Hossein Kashfi et al.
Oncotarget (2018)
Toward Immunocompetent 3D Skin Models
Aleta Pupovac et al.
ADVANCED HEALTHCARE MATERIALS (2018)
Organoid and Enteroid Modeling of Salmonella Infection
Yuebang Yin et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
Sigrid A. Langhans
FRONTIERS IN PHARMACOLOGY (2018)
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
Cindy J. M. Loomans et al.
STEM CELL REPORTS (2018)
Progress and potential in organoid research
Giuliana Rossi et al.
NATURE REVIEWS GENETICS (2018)
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
Xiaodun Li et al.
NATURE COMMUNICATIONS (2018)
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
Huili Hu et al.
CELL (2018)
Inflammatory Cytokine TNF alpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
Weng Chuan Peng et al.
CELL (2018)
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition
Masayuki Fujii et al.
CELL STEM CELL (2018)
Tubular organotypic culture model of human kidney
Dae-Young Jun et al.
PLOS ONE (2018)
Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
Hanxiao Xu et al.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2018)
Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids
Steven D. Forsythe et al.
FRONTIERS IN PUBLIC HEALTH (2018)
The 3Rs in research: a contemporary approach to replacement, reduction and refinement
Judy MacArthur Clark
BRITISH JOURNAL OF NUTRITION (2018)
Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies
George A. Truskey
FRONTIERS IN PUBLIC HEALTH (2018)
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
Miguel Crespo et al.
NATURE MEDICINE (2017)
Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening
Robson L. F. Amaral et al.
FRONTIERS IN PHYSIOLOGY (2017)
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity
Shih-Yu Chang et al.
JCI INSIGHT (2017)
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery
Fleur Weeber et al.
CELL CHEMICAL BIOLOGY (2017)
Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies
Wenqi Lu et al.
DRUG METABOLISM AND DISPOSITION (2017)
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
Jorge O. Munera et al.
CELL STEM CELL (2017)
Self-organized developmental patterning and differentiation in cerebral organoids
Magdalena Renner et al.
EMBO JOURNAL (2017)
Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro
Samuel S. Pendergraft et al.
BIOLOGY OF REPRODUCTION (2017)
Modeling Development and Disease with Organoids
Hans Clevers
CELL (2016)
3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors
Zhongwei Li et al.
CELL STEM CELL (2016)
Organoids: Modeling Development and the Stem Cell Niche in a Dish
Kai Kretzschmar et al.
DEVELOPMENTAL CELL (2016)
Generation of kidney organoids from human pluripotent stem cells
Minoru Takasato et al.
NATURE PROTOCOLS (2016)
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
Laura Broutier et al.
NATURE PROTOCOLS (2016)
Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals
Katherine E. Williams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
Johanna F. Dekkers et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Rhiannon M. David et al.
TOXICOLOGY RESEARCH (2016)
A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro
Philipp Schlaermann et al.
GUT (2016)
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Meritxell Huch et al.
CELL (2015)
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
Marc van de Wetering et al.
CELL (2015)
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj et al.
CELL (2015)
CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures
Jun Terashima et al.
DRUG METABOLISM AND PHARMACOKINETICS (2015)
In vitro skin models as a tool in optimization of drug formulation
Goril Eide Flaten et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
Sina Bartfeld et al.
GASTROENTEROLOGY (2015)
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
Minoru Takasato et al.
NATURE (2015)
Nephron organoids derived from human pluripotent stem cells model kidney development and injury
Ryuji Morizane et al.
NATURE BIOTECHNOLOGY (2015)
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids
Ling Huang et al.
NATURE MEDICINE (2015)
Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo
Stacy R. Finkbeiner et al.
STEM CELL REPORTS (2015)
Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro
Eleanor Knight et al.
JOURNAL OF ANATOMY (2015)
Animal models of human disease: Inflammation
David R. Webb
BIOCHEMICAL PHARMACOLOGY (2014)
Animal models of disease: Pre-clinical animal models of cancer and their applications and utility in drug discovery
Bruce A. Ruggeri et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model
Anna I. Astashkina et al.
BIOMATERIALS (2014)
Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells
Atsuhiro Taguchi et al.
CELL STEM CELL (2014)
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
Kyle W. McCracken et al.
NATURE (2014)
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
M. Takasato et al.
NATURE CELL BIOLOGY (2014)
An in vivo model of human small intestine using pluripotent stem cells
Carey L. Watson et al.
NATURE MEDICINE (2014)
Organogenesis in a dish: Modeling development and disease using organoid technologies
Madeline A. Lancaster et al.
SCIENCE (2014)
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Hans Clevers et al.
SCIENCE (2014)
Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy
T. Grabinger et al.
CELL DEATH & DISEASE (2014)
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Gerald Schwank et al.
CELL STEM CELL (2013)
Artificial three-dimensional niches deconstruct pancreas development in vitro
Chiara Greggio et al.
DEVELOPMENT (2013)
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Meritxell Huch et al.
EMBO JOURNAL (2013)
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Meritxell Huch et al.
NATURE (2013)
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe et al.
NATURE (2013)
Cerebral organoids model human brain development and microcephaly
Madeline A. Lancaster et al.
NATURE (2013)
A functional CFTR assay using primary cystic fibrosis intestinal organoids
Johanna F. Dekkers et al.
NATURE MEDICINE (2013)
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
Ulrich M. Zanger et al.
PHARMACOLOGY & THERAPEUTICS (2013)
The development of a 3D immunocompetent model of human skin
David Y. S. Chau et al.
BIOFABRICATION (2013)
Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)
Christine Goetz et al.
EXPERIMENTAL DERMATOLOGY (2012)
Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
Stacy R. Finkbeiner et al.
MBIO (2012)
Repetitive Exposure to Zinc Oxide Nanoparticles Induces DNA Damage in Human Nasal Mucosa Mini Organ Cultures
Stephan Hackenberg et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2011)
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
Toshiro Sato et al.
GASTROENTEROLOGY (2011)
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
Jason R. Spence et al.
NATURE (2011)
Self-organizing optic-cup morphogenesis in three-dimensional culture
Mototsugu Eiraku et al.
NATURE (2011)
Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models
Christine Jaeckh et al.
TOXICOLOGY IN VITRO (2011)
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Nick Barker et al.
CELL STEM CELL (2010)
Nicotine and methyl methane sulfonate in mini organ cultures of human parotid gland tissue
Christian Ginzkey et al.
TOXICOLOGY LETTERS (2010)
Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?
Giovanna Mazzoleni et al.
GENES AND NUTRITION (2009)
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Toshiro Sato et al.
NATURE (2009)
Recent advances in three-dimensional multicellular spheroid culture for biomedical research
Ruei-Zhen Lin et al.
Biotechnology Journal (2008)
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker et al.
NATURE (2007)
The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®:: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport
F Netzaff et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2005)
The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology
NH Kleinsasser et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2004)
Concordance of the toxicity of pharmaceuticals in humans and in animals
H Olson et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2000)