期刊
MOVEMENT DISORDERS
卷 36, 期 10, 页码 2435-2440出版社
WILEY
DOI: 10.1002/mds.28741
关键词
EEG microstates; synucleinopathy; medication-naive; MCI-LB; prodromal DLB
资金
- Ministry of Health of the Czech Republic [NU20-04-00294]
- MEYS CR [LM2018129]
This study found altered temporal dynamics of EEG microstates in patients with mild cognitive impairment with Lewy bodies, with higher occurrence of microstates A-D in the patient group. Specifically, microstate B showed shorter mean duration and correlation with the dominant alpha frequency in the patient group.
Background Electrophysiological markers of prodromal dementia with Lewy bodies were described in the spectral domain. The sub-second temporal resolution may provide additional information. Objective To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies and to assess the association between their temporal dynamics and the spectral marker. Methods Temporal parameters of microstates were compared between 21 patients with mild cognitive impairment with Lewy bodies and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Results Microstates A-D showed higher occurrence in the patient group. Microstate B additionally revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. Conclusions Temporal dynamics of all EEG microstates were altered in medication-naive subjects with prodromal dementia with Lewy bodies. Longitudinal follow-up may reveal how EEG microstates reflect progression of brain function deficits and effects of treatment manipulations. (c) 2021 International Parkinson and Movement Disorder Society
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