4.6 Article

Coptisine Attenuates Diabetes-Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

期刊

MOLECULES
卷 26, 期 14, 页码 -

出版社

MDPI
DOI: 10.3390/molecules26144210

关键词

coptisine; diabetes; endoplasmic reticulum stress; endothelial dysfunction; oxidative stress

资金

  1. Research Committee of the University of Macau [SRG2019-00154-ICMS, MYRG2019-00157-ICMS]
  2. major basic and applied basic research projects of Guangdong Province of China [2019B 030302005]
  3. Science and Technology Development Fund, Macau SAR [0013/2019/AFJ]

向作者/读者索取更多资源

The study showed that coptisine can improve vascular function in diabetic patients by suppressing ER stress and oxidative stress, enhancing endothelium-dependent relaxation, indicating the therapeutic potential of coptisine for treating diabetic vasculopathy.
Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Coptisine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas and carotid arteries were obtained from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) and coptisine. Some arterial rings were obtained from diabetic mice, which were induced by high-fat diet (45% kcal% fat) feeding for 6 weeks combined with a low-dose intraperitoneal injection of streptozotocin (120 mg/kg). Functional studies showed that coptisine protected endothelium-dependent relaxation in aortas against risk factors and from diabetic mice. Coptisine increased phosphorylations of AMPK and eNOS and downregulated the endoplasmic reticulum (ER) stress markers as determined by Western blotting. Coptisine elevates NO bioavailability and decreases reactive oxygen species level. The results indicate that coptisine improves vascular function in diabetes through suppression of ER stress and oxidative stress, implying the therapeutic potential of coptisine to treat diabetic vasculopathy.

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