4.6 Review

3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature

期刊

MOLECULES
卷 26, 期 13, 页码 -

出版社

MDPI
DOI: 10.3390/molecules26134066

关键词

3D-printing; additive manufacturing; implant; drug-eluting

资金

  1. Federal Ministry of Education and Research of Germany (BMBF)
  2. DFG (German Research Foundation) [393148499]
  3. University of Greifswald

向作者/读者索取更多资源

The use of 3D printing technology for drug-eluting implants combines targeted local drug therapy with precise disease location and individualized needs. Research has focused on various materials and printing techniques to achieve implants with different properties, showing great potential in multiple application fields.
The usage of 3D-printing for drug-eluting implants combines the advantages of a targeted local drug therapy over longer periods of time at the precise location of the disease with a manufacturing technique that easily allows modifications of the implant shape to comply with the individual needs of each patient. Research until now has been focused on several aspects of this topic such as 3D-printing with different materials or printing techniques to achieve implants with different shapes, mechanical properties or release profiles. This review is intended to provide an overview of the developments currently described in the literature. The topic is very multifaceted and several of the investigated aspects are not related to just one type of application. Consequently, this overview deals with the topic of 3D-printed drug-eluting implants in the application fields of stents and catheters, gynecological devices, devices for bone treatment and surgical screws, antitumoral devices and surgical meshes, as well as other devices with either simple or complex geometry. Overall, the current findings highlight the great potential of the manufacturing of drug-eluting implants via 3D-printing technology for advanced individualized medicine despite remaining challenges such as the regulatory approval of individualized implants.

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