3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles

In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various alpha-nitroketones using chloramine-T as the base. The scope of alpha-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.

Automated summary

In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various alpha-nitroketones using chloramine-T as the base. The range of alpha-nitroketones and alkenes used was extensive, producing a variety of isoxazolines and isoxazoles. The use of chloramine-T as a low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition was found to be attractive.