期刊
MOLECULES
卷 26, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules26164720
关键词
calcium; androgen deficiency; bone; aging; achiote
资金
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior [1723/2018-00 PROCAD-AMAZONIA]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [402332/2013-0]
This study demonstrated that co-treatment with annatto products, such as purified annatto oil or its granules, had a more significant improvement on blood lipid profile and bone integrity compared to testosterone alone. The co-treatment also improved some endpoints not affected by testosterone reposition alone, suggesting a synergistic effect between annatto products and testosterone in promoting bone health. Overall, the granules had better results than purified annatto oil.
This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic(R)) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). Our results show that orchiectomy could significantly change the blood lipid profile and decrease bone integrity parameters. Testosterone reposition alone could improve some endpoints, including LDL, TC, bone weight, and bone calcium concentration. However, other parameters were not significantly improved. Co-treatment with PAO or GRA improved the blood lipid profile and bone integrity more significantly and improved some endpoints not affected by testosterone reposition alone (such as TG levels and trabeculae sizes). The results suggest that co-treatment with annatto products improved the blood lipid profile and the anti-osteoporosis effects of testosterone. Overall, GRA had better results than PAO.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据