期刊
MOLECULES
卷 26, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/molecules26144281
关键词
glycolipids; neoglycolipids; dendrimers; liposomes; dendrimersomes; carbohydrates
资金
- Natural Science and Engineering Research Council of Canada (NSERC) [70732101]
- Canadian Research Chair [950-222204]
- Fonds du Quebec-Nature et Technologies [206687]
- Ministry of Economy and Innovation (MEI) [PSR-SIIRI-982]
Researchers have made systematic progress in the design of synthetic glycolipid analogs by combining dendrimer chemistry with neoglycolipid syntheses, creating novel glycoarchitectures that eliminate the need for additional lipids to enhance stability.
This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-group and two hydrophobic lipid tails embedded in the lipid bilayers of the cell membranes, they usually require extraneous lipids (phosphatidylcholine, cholesterol) to confer their stability. In order to obviate the necessity for these additional stabilizing ingredients, recent investigations have merged dendrimer chemistry with that of neoglycolipid syntheses. This singular approach has provided novel glycoarchitectures allowing reconsidering the necessity for the traditional one to two hydrophilic/hydrophobic ratio. An emphasis has been provided in the recent design of modular arborescent neoglycolipid syntheses coined glycodendrimersomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据