4.6 Article

Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in C. elegans Model of Parkinson's Disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nutrition & Dietetics

Antistress and anti-aging activities ofCaenorhabditis eleganswere enhanced byMomordicasaponin extract

Chunxiu Lin et al.

Summary: Momordica saponin extract (MSE) not only improves longevity and neuroprotection, but also alleviates fat accumulation inCaenorhabditis elegans. MSE shows strong antioxidant activities by increasing SOD and CAT activities, reducing ROS and lipid oxidation. Furthermore, MSE upregulates the expression of stress resistance genes and induces nuclear DAF-16::GFP localization, suggesting its potential as a nutraceutical in geriatric research.

EUROPEAN JOURNAL OF NUTRITION (2021)

Article Chemistry, Medicinal

Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus

Koji Fujihara et al.

Summary: In this study, six new triterpene saponins and three known saponins were isolated from MeOH extracts of the cactus Stenocereus pruinosus. The isolated saponins were characterized using MS, IR, and comprehensive NMR measurements. Evaluation of the saponins for inhibition of BACE1 activity and amyloid beta aggregation showed potential for drug development for Alzheimer's disease, with stenoside A exhibiting inhibitory activity related to A beta aggregation.

JOURNAL OF NATURAL MEDICINES (2021)

Article Pharmacology & Pharmacy

Frondoside A Attenuates Amyloid-β Proteotoxicity in Transgenic Caenorhabditis elegans by Suppressing Its Formation

Taweesak Tangrodchanapong et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Agriculture, Multidisciplinary

Ginsenoside Rg3 Prevents Cognitive Impairment by Improving Mitochondrial Dysfunction in the Rat Model of Alzheimer's Disease

Yan Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Medicine, Research & Experimental

Anti-Parkinson activity of bioactive substances extracted from Holothuria leucospilota

Nawaphat Malaiwong et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Geriatrics & Gerontology

New Perspectives on Roles of Alpha-Synuclein in Parkinson's Disease

Guoxin Zhang et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Behavioral Sciences

Motor symptoms in Parkinson's disease: A unified framework

Ahmed A. Moustafa et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Genetics & Heredity

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

Rafael L. Gomez-Amaro et al.

GENETICS (2015)

Article Genetics & Heredity

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

Rafael L. Gomez-Amaro et al.

GENETICS (2015)

Review Chemistry, Multidisciplinary

Superoxide Dismutases and Superoxide Reductases

Yuewei Sheng et al.

CHEMICAL REVIEWS (2014)

Article Geriatrics & Gerontology

Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease

Jackalina M. Van Kampen et al.

EXPERIMENTAL GERONTOLOGY (2014)

Review Medicine, General & Internal

Pharmacological Treatment of Parkinson Disease A Review

Barbara S. Connolly et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Review Clinical Neurology

Targeting heat shock proteins to modulate alpha-synuclein toxicity

Daryl Rhys Jones et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2014)

Review Chemistry, Multidisciplinary

Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers

Joo-In Park et al.

FRONTIERS IN CHEMISTRY (2014)

Article Neurosciences

Effects of α-Synuclein Overexpression in Transgenic Caenorhabditis elegans Strains

Rakesh Bodhicharla et al.

CNS & Neurological Disorders-Drug Targets (2013)

Article Oncology

Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2

Xinrong Ma et al.

BREAST CANCER RESEARCH AND TREATMENT (2012)

Article Medicine, Research & Experimental

Programmed Cell Death in Parkinson's Disease

Katerina Venderova et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Integrative & Complementary Medicine

Neuroprotective effects of ginsenosides Rh-1 and Rg(2) on neuronal cells

Xiao-Fan Li et al.

CHINESE MEDICINE (2011)

Article Pharmacology & Pharmacy

Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin

Lingling Yang et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity

Xu Liangliang et al.

MOLECULAR BIOLOGY REPORTS (2010)

Article Biochemistry & Molecular Biology

Suppression of in vivo β-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein

Virginia Fonte et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Clinical Neurology

Estimated life expectancy of Parkinson's patients compared with the UK population

Lianna S. Ishihara et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2007)

Article Biochemistry & Molecular Biology

20(S)-ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway

Jeong-Ki Min et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Cell Biology

Developmental apoptosis in C-elegans:: a complex CEDnario

G Lettre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons

S Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Pharmacology & Pharmacy

Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress

XC Chen et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2003)

Article Multidisciplinary Sciences

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

R Nass et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Neurosciences

Proteasomal function is impaired in substantia nigra in Parkinson's disease

KSP McNaught et al.

NEUROSCIENCE LETTERS (2001)