Trimeric and Dimeric Carbazole Alkaloids from Murraya microphylla

Seventeen new carbazole alkaloid derivatives, including a trimeric carbazole racemate, (+/-)-microphyltrine A (1), 15 dimeric carbazole racemates, (+/-)-microphyldines A-O (2-16), and a C-6-C-3 ''-methyl-linked dimeric carbazole, microphyldine P (17), were isolated from the leaves and stems of Murraya microphylla (Merr. et Chun) Swingle. The structures of the new compounds were elucidated on the basis of HRESIMS and NMR data analysis. The optically pure isomers of these isolated carbazole alkaloids were obtained by chiral HPLC separation and their absolute configurations were determined by electronic circular dichroism (ECD) data analysis.

Automated summary

In this study, seventeen new carbazole alkaloid derivatives were isolated from the leaves and stems of Murraya microphylla, including trimeric and dimeric carbazole racemates. The structures of the new compounds were elucidated using HRESIMS and NMR data analysis, and the optically pure isomers were obtained through chiral HPLC separation.