期刊
MOLECULES
卷 26, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules26123594
关键词
peptaibol; Clonostachys rosea; Merkel cell carcinoma
资金
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
- National Institutes of Health [HHSN261200800001E]
A new linear peptide named roseabol A (1) and a known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the fungus Clonostachys rosea. Roseabol A (1) contains amino acid residues characteristic of the peptaibol family of peptides, while compound 2 showed inhibitory activity against Merkel cell carcinoma.
A new 11 amino acid linear peptide named roseabol A (1) and the known compound 13-oxo-trans-9,10-epoxy-11(E)-octadecenoic acid (2) were isolated from the fungus Clonostachys rosea. Combined NMR and MS analysis revealed that roseabol A (1) contained amino acid residues characteristic of the peptaibol family of peptides such as isovaline, alpha-aminoisobutyric acid, hydroxyproline, leucinol, and an N-terminal isovaleric acid moiety. The amino acid sequence was established by a combination of NMR studies and tandem MS fragmentation analyses, and the absolute configurations of the constituent amino acids of 1 were determined by the advanced Marfey's method. Compound 2 showed inhibitory activity against Merkel cell carcinoma, a rare and difficult-to-treat type of skin cancer, with an IC50 value of 16.5 mu M.
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