期刊
MOLECULES
卷 26, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules26175383
关键词
pyrazolo[5,1-b]thiazole; X-ray crystallography; antibacterial activity; antifungal activity; anticancer activity
资金
- Deanship of Scientific Research, King Khalid University
A convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out in this study, and the synthesized compounds were characterized and evaluated for antimicrobial and anticancer activities, showing promising results. These products could potentially serve as leading compounds for future drug molecule design.
The pharmacological activities of thiazole and pyrazole moieties as antimicrobial and anticancer agents have been thoroughly described in many literature reviews. In this study, a convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out. The synthesized compounds were characterized by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some selected examples were screened and evaluated for their antimicrobial and anticancer activities and showed promising results. These products could serve as leading compounds in the future design of new drug molecules.
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