期刊
MOLECULES
卷 26, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules26123527
关键词
daptomycin; monoliths; enantioselective; nano-HPLC
资金
- Al-Azhar University in Egypt
- University of Canberra in Australia
- Cultural Affairs and Missions Sector Ministry of Higher Education, Egypt
Daptomycin, a macrocyclic antibiotic, was used as a new chiral selector in the preparation of a chiral stationary phase in a polymer monolithic capillary. The capillaries prepared showed baseline separation for many racemic drugs under reversed-phase HPLC, expanding the horizons of chiral selectors in HPLC.
Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据