期刊
MOLECULES
卷 26, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules26164848
关键词
immunotherapy; immune checkpoint; PD-L1; PD-1; macrocyclic peptides
资金
- National Science Centre, Poland [UMO-2017/25/B/NZ1/00827]
Researchers have reported the crystal structure of a macrocyclic peptide inhibitor (peptide 104) bound to PD-L1, which shows a unique binding mode compared to another peptide of the same family. The binding mode is primarily driven by extensive hydrophobic interactions at the center of the binding surface and an electrostatic patch at the side. A sulfur/pi interaction supports the binding of the macrocycle to the receptor.
The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (peptide 104) in complex with PD-L1. Our structure shows no indication of an unusual bifurcated binding mode demonstrated earlier for another peptide of the same family (peptide 101). The binding mode relies on extensive hydrophobic interactions at the center of the binding surface and an electrostatic patch at the side. An interesting sulfur/pi interaction supports the macrocycle-receptor binding. Overall, our results allow a better understanding of forces guiding macrocycle affinity for PD-L1, providing a rationale for future structure-based inhibitor design and rational optimization.
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