期刊
MOLECULES
卷 26, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules26164871
关键词
Rhodococcus; single-cell oil; biofactory
资金
- PIP-CONICET [0529]
- SCyT-UNPSJB
- Proy. PUE-INBIOP-CONICET [0033]
Bacteria belonging to the Rhodococcus genus have the ability to produce significant amounts of triacylglycerols (TAG) and can be considered as oleaginous microorganisms. They possess specific physiological properties and molecular mechanisms that differentiate them from other microorganisms. These bacteria can degrade a wide range of carbon sources and utilize industrial wastes for oil production. Studying genetic and metabolic approaches can help improve their ability to produce fatty acids.
Bacteria belonging to the Rhodococcus genus are frequent components of microbial communities in diverse natural environments. Some rhodococcal species exhibit the outstanding ability to produce significant amounts of triacylglycerols (TAG) (>20% of cellular dry weight) in the presence of an excess of the carbon source and limitation of the nitrogen source. For this reason, they can be considered as oleaginous microorganisms. As occurs as well in eukaryotic single-cell oil (SCO) producers, these bacteria possess specific physiological properties and molecular mechanisms that differentiate them from other microorganisms unable to synthesize TAG. In this review, we summarized several of the well-characterized molecular mechanisms that enable oleaginous rhodococci to produce significant amounts of SCO. Furthermore, we highlighted the ability of these microorganisms to degrade a wide range of carbon sources coupled to lipogenesis. The qualitative and quantitative oil production by rhodococci from diverse industrial wastes has also been included. Finally, we summarized the genetic and metabolic approaches applied to oleaginous rhodococci to improve SCO production. This review provides a comprehensive and integrating vision on the potential of oleaginous rhodococci to be considered as microbial biofactories for microbial oil production.
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