4.6 Article

Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

期刊

MOLECULES
卷 26, 期 11, 页码 -

出版社

MDPI
DOI: 10.3390/molecules26113388

关键词

mass spectrometry; two-dimensional; tandem mass spectrometry; phase correction; absorption mode; data processing

资金

  1. Der Wissenschaftsfonds (Austrian Science Fund)
  2. Lise Meitner Fellowship [M 2757-B]
  3. Austrian Science Fund (FWF)

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Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that correlates precursor and fragment ion signals by manipulating ion motions. Phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios and resolving power significantly, making data interpretation easier.
Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.

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