期刊
MOLECULAR THERAPY
卷 29, 期 9, 页码 2794-2805出版社
CELL PRESS
DOI: 10.1016/j.ymthe.2021.08.001
关键词
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资金
- National Key R&D Program of China [2018YFC1313300]
- National Natural Science Foundation of China [81070362, 81172470, 81372629, 81772627, 81874073, 81974384]
- Nature Science Foundation of Hunan Province [2015JC3021, 2016JC2037]
- Beijing CSCO Clinical Oncology Research Foundation [Y-HR2019-0182, Y-2019Genecast-043]
- Fundamental Research Funds for the Central Universities of Central South University University [2020zzts273, 2019zzts797]
The numbers of COVID-19 cases and deaths are increasing, with vaccine efficacy exceeding 70% and RNA-based vaccines being the most effective at 94.29%. The most common vaccine-related adverse reactions are pain, fatigue, and headache, with most reactions being mild, although severe reactions such as thromboembolic events have been identified.
The numbers of cases and deaths from coronavirus disease 2019 (COVID-19) are continuously increasing. Many people are concerned about the efficacy and safety of the COVID-19 vaccines. We performed a comprehensive analysis of the published trials of COVID-19 vaccines and the real-world data from the Vaccine Adverse Event Reporting System. Globally, our research found that the efficacy of all vaccines exceeded 70%, and RNA-based vaccines had the highest efficacy of 94.29%; moreover, Black or African American people, young people, and males may experience greater vaccine efficacy. The spectrum of vaccine-related adverse drug reactions (ADRs) is extremely broad, and the most frequent ADRs are pain, fatigue, and headache. Most ADRs are tolerable and are mainly grade 1 or 2 in severity. Some severe ADRs have been identified (thromboembolic events, 21-75 cases per million doses; myocarditis/pericarditis, 2-3 cases per million doses). In summary, vaccines are a powerful tool that can be used to control the COVID-19 pandemic, with high efficacy and tolerable ADRs. In addition, the spectrum of ADRs associated with the vaccines is broad, and most of the reactions appear within a week, although some may be delayed. Therefore, ADRs after vaccination need to be identified and addressed in a timely manner.
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