期刊
MOLECULAR PSYCHIATRY
卷 27, 期 1, 页码 640-651出版社
SPRINGERNATURE
DOI: 10.1038/s41380-021-01181-3
关键词
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资金
- National Institutes of Health [F30-MH115536, R01-DA047269, R01-DA035217, R01-MH121454]
- Research and Education Initiative Fund, a component of the Advancing a Healthier Wisconsin endowment at the Medical College of Wisconsin
- NIGMS [T32-GM080202]
The neurobiology of addiction has been a focus of research for over 50 years, with recent technological advancements such as optogenetics and miniaturized single-photon microscopy shedding light on the cellular and circuit mechanisms of addiction.
The neurobiology of addiction has been an intense topic of investigation for more than 50 years. Over this time, technological innovation in methods for studying brain function rapidly progressed, leading to increasingly sophisticated experimental approaches. To understand how specific brain regions, cell types, and circuits are affected by drugs of abuse and drive behaviors characteristic of addiction, it is necessary both to observe and manipulate neural activity in addiction-related behavioral paradigms. In pursuit of this goal, there have been several key technological advancements in in vivo imaging and neural circuit modulation in recent years, which have shed light on the cellular and circuit mechanisms of addiction. Here we discuss some of these key technologies, including circuit modulation with optogenetics, in vivo imaging with miniaturized single-photon microscopy (miniscope) and fiber photometry, and how the application of these technologies has garnered novel insights into the neurobiology of addiction.
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