期刊
MOLECULAR ONCOLOGY
卷 15, 期 12, 页码 3706-3720出版社
WILEY
DOI: 10.1002/1878-0261.13081
关键词
Ewing sarcoma; EWS-FLI1; near-infrared imaging; surgical guidance; targeting peptide
类别
资金
- Hubei Province Scientific and Technical Innovation Key Project [2019ACA136]
- Leading Medical Talent of Hubei Province
- Scientific research project of Hubei province Health Commission [WJ2019H071]
- National Natural Science Foundation of China [21572174]
Ewing sarcoma is an aggressive pediatric tumor with limited diagnostic tools. A near-infrared fluorescent probe targeting the specific fusion protein EWS-FLI1 was synthesized, showing promising results in identifying tumor boundaries and lymph node metastases in animal models. This probe has the potential for early diagnosis and surgical guidance of Ewing sarcoma through molecularly targeted NIR imaging.
Ewing sarcoma (ES) is one of the most aggressive types of pediatric tumors. The lack of tools for the identification of ES has largely hindered clinical diagnosis and the improvement of treatment. To address this challenge, we synthesized a near-infrared (NIR) fluorescent probe (CS2-N-E9R) that targets the ES-specific fusion protein EWS-FLI1 (E/F). This probe exhibited specific and high binding affinity to E/F. Further studies in animal models showed that CS2-N-E9R can be used to identify the boundaries of ES and lymph node metastases under a complex biological environment. These results demonstrate that CS2-N-E9R is a promising probe for early diagnosis and surgical guidance of ES through molecularly targeted NIR imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据