4.7 Article

MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages

期刊

MOLECULAR NUTRITION & FOOD RESEARCH
卷 65, 期 16, 页码 -

出版社

WILEY
DOI: 10.1002/mnfr.202001203

关键词

dietary fatty acids; hematopoiesis; MUFAs; obesity; progenitor cells; stem cells

资金

  1. Spanish Ministry of Science, Innovation and Universities [AGL2016-80852-R]
  2. V Own Research Plan of the University of Seville (VPPI-US)
  3. European Social Fund
  4. CSIC/Juan de la Cierva [FJCI-2017-33132]

向作者/读者索取更多资源

This study reveals that altering the types of fatty acids in the diet can influence the generation and trafficking of immune cells in obesity, with diets rich in MUFAs playing a beneficial role in combating dysfunctional immune systems induced by obesity.
Scope The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. Methods and Results C57BL/6J mice are randomly assigned to isocaloric high-fat diets (HFDs) formulate with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs fortified with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by profiling of the obese metabolic phenotype and immunophenotypic features of immune cells in blood, spleen, and BM. All HFDs induce an obese phenotype, but it becomes largely less disruptive after the HFDs are enriched in MUFAs, which also induce signs of granulopoiesis and an expansion of long-term hematopoietic stem and granulocyte-macrophage progenitor cells in BM. In contrast, a HFD enriched in SFAs disturbs the fitness of medullary lymphocytes and promotes monopoiesis in favor of pro-inflammatory activated subsets. Conclusion The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems.

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