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Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
Gen Matsumoto et al.
MOLECULAR CELL (2011)
Pathological roles of α-synuclein in neurological disorders (vol 10, pg 1015, 2011)
K. Vekrellis et al.
LANCET NEUROLOGY (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
Peter M. Andersen et al.
NATURE REVIEWS NEUROLOGY (2011)
Clinical diagnosis and management of amyotrophic lateral sclerosis
Orla Hardiman et al.
NATURE REVIEWS NEUROLOGY (2011)
Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
Troy T. Rohn et al.
NEUROBIOLOGY OF DISEASE (2011)
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease
Yuncheng Wu et al.
NEUROSIGNALS (2011)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
Smita Majumder et al.
PLOS ONE (2011)
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Philipp Wild et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Pathological roles of α-synuclein in neurological disorders
Kostas Vekrellis et al.
LANCET NEUROLOGY (2011)
Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
Gyungah Jun et al.
ARCHIVES OF NEUROLOGY (2010)
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Lydia Alvarez-Erviti et al.
ARCHIVES OF NEUROLOGY (2010)
A comprehensive glossary of autophagy-related molecules and processes
Daniel J. Klionsky et al.
AUTOPHAGY (2010)
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee et al.
CELL (2010)
Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders
Maria Xilouri et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
The Beclin 1 interactome
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CURRENT OPINION IN CELL BIOLOGY (2010)
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Claudia Rose et al.
HUMAN MOLECULAR GENETICS (2010)
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
Valeria Crippa et al.
HUMAN MOLECULAR GENETICS (2010)
Lysosomal Degradation of α-Synuclein in Vivo
Sally K. Mak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases
Maurizio Renna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
α-Synuclein impairs macroautophagy: implications for Parkinson's disease
Ashley R. Winslow et al.
JOURNAL OF CELL BIOLOGY (2010)
The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
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MOLECULAR CELL (2010)
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
Peter O. Bauer et al.
NATURE BIOTECHNOLOGY (2010)
Autophagy in mammalian development and differentiation
Noboru Mizushima et al.
NATURE CELL BIOLOGY (2010)
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
Marta Martinez-Vicente et al.
NATURE NEUROSCIENCE (2010)
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Jose A. Rodriguez-Navarro et al.
NEUROBIOLOGY OF DISEASE (2010)
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Jane O. Johnson et al.
NEURON (2010)
Fifteen-year quest for microphthalmia-associated transcription factor target genes
Yann Cheli et al.
PIGMENT CELL & MELANOMA RESEARCH (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice
Shuqiu Zheng et al.
PLOS GENETICS (2010)
Autophogy protects neuron from Aβ-induced cytotoxicity
Shih-Ya Hung et al.
AUTOPHAGY (2009)
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
Carol A. Mercer et al.
AUTOPHAGY (2009)
Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Hyunkyung Jeong et al.
CELL (2009)
Autophagy in disease: a double-edged sword with therapeutic potential
Wim Martinet et al.
CLINICAL SCIENCE (2009)
Molecular pathogenesis of Parkinson disease: insights from genetic studies
Thomas Gasser
EXPERT REVIEWS IN MOLECULAR MEDICINE (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz et al.
GENES & DEVELOPMENT (2009)
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Yipeng Wang et al.
HUMAN MOLECULAR GENETICS (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
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JOURNAL OF NEUROCHEMISTRY (2009)
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
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JOURNAL OF NEUROSCIENCE (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
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MOLECULAR BIOLOGY OF THE CELL (2009)
A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
Vladimir Kirkin et al.
MOLECULAR CELL (2009)
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
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NATURE GENETICS (2009)
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
Teresa L. M. Thurston et al.
NATURE IMMUNOLOGY (2009)
Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
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PLOS ONE (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
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SCIENCE (2009)
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
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MOLECULAR BRAIN (2009)
α-synuclein degradation by autophagic pathways -: A potential key to Parkinson's disease pathogenesis
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AUTOPHAGY (2008)
A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy
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AUTOPHAGY (2008)
Altered macroautophagy in the spinal cord of S0D1 mutant mice
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AUTOPHAGY (2008)
Huntington's disease: from pathology and genetics to potential therapies
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BIOCHEMICAL JOURNAL (2008)
Cathepsin D is the main lysosomal enzyme involved in the degradation of α-synuclein and generation of its carboxy-terminally truncated species
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BIOCHEMISTRY (2008)
Autophagy in the pathogenesis of disease
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CELL (2008)
Mechanisms of neurodegeneration in Huntington's disease
Joana M. Gil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Huntington's disease: degradation of mutant huntingtin by autophagy
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FEBS JOURNAL (2008)
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Wild type α-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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JOURNAL OF CELL BIOLOGY (2008)
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
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JOURNAL OF CLINICAL INVESTIGATION (2008)
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
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JOURNAL OF NEUROCHEMISTRY (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
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JOURNAL OF NEUROSCIENCE (2008)
Autophagy fights disease through cellular self-digestion
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NATURE (2008)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
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NATURE CHEMICAL BIOLOGY (2008)
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
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NEUROSCIENCE (2008)
Lithium delays progression of amyotrophic lateral sclerosis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
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BRAIN RESEARCH (2007)
Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae
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FEBS LETTERS (2007)
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
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NEUROLOGY (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Metformin therapy in a transgenic mouse model of Huntington's disease
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NEUROSCIENCE LETTERS (2007)
ALS:: A disease of motor neurons and their nonneuronal neighbors
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NEURON (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
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NATURE GENETICS (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
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NATURE (2006)
Rapamycin alleviates toxicity of different aggregate-prone proteins
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HUMAN MOLECULAR GENETICS (2006)
Model-guided microarray implicates the retromer complex in Alzheimer's disease
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ANNALS OF NEUROLOGY (2005)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
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JOURNAL OF CELL BIOLOGY (2005)
Macroautophagy -: a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
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JOURNAL OF CELL BIOLOGY (2005)
Lithium induces autophagy by inhibiting inositol monophosphatase
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JOURNAL OF CELL BIOLOGY (2005)
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
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AUTOPHAGY (2005)
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
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AUTOPHAGY (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
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NATURE GENETICS (2004)
Role for Rab7 in maturation of late autophagic vacuoles
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JOURNAL OF CELL SCIENCE (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
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SCIENCE (2004)
Protein aggregation and neurodegenerative disease
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NATURE MEDICINE (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
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NATURE GENETICS (2004)
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
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JOURNAL OF CELL SCIENCE (2004)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course
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BRAIN (2003)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
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CELL (2002)
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
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HUMAN MOLECULAR GENETICS (2002)
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JOURNAL OF BACTERIOLOGY (2001)
Neurodegenerative tauopathies
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ANNUAL REVIEW OF NEUROSCIENCE (2001)
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
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NATURE (2000)
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