Role of long noncoding RNA taurine-upregulated gene 1 in cancers

Long non-coding RNAs (lncRNAs) are a group of non-protein coding RNAs with a length of more than 200 bp. The lncRNA taurine up-regulated gene 1 (TUG1) is abnormally expressed in many human malignant cancers, where it acts as a competitive endogenous RNA (ceRNA), regulating gene expression by specifically sponging its corresponding microRNAs. In the present review, we summarised the current understanding of the role of lncRNA TUG1 in cancer cell proliferation, metastasis, angiogenesis, chemotherapeutic drug resistance, radiosensitivity, cell regulation, and cell glycolysis, as well as highlighting its potential application as a clinical biomarker or therapeutic target for malignant cancer. This review provides the basis for new research directions for lncRNA TUG1 in cancer prevention, diagnosis, and treatment.

Automated summary

The abnormally expressed long non-coding RNA (lncRNA) TUG1 plays a critical role in regulating gene expression in malignant tumors, making it a potential clinical biomarker or therapeutic target for cancer. This review provides a basis for new research directions in cancer prevention, diagnosis, and treatment involving lncRNA TUG1.