期刊
MOLECULAR DIVERSITY
卷 26, 期 3, 页码 1663-1674出版社
SPRINGER
DOI: 10.1007/s11030-021-10294-4
关键词
Synthesis; Domino strategy; Water; Pyrrolo[3,2-c]pyridine
The catalyst-free domino reaction in water for synthesizing pyrrolo[3,2-c]pyridine derivatives shows high yields and is characterized by simple and efficient operation.
A strategy for catalyst-free domino reaction of 4-aminopyridin-2(1H)-ones, arylglyoxal hydrates and different 1,3-dicarbonyl compounds in water has been established. The mild and efficient procedure afforded pyrrolo[3,2-c]pyridine derivatives with 76-94% yields after simple crystallization. The present procedure shows promising characteristics, such as readily available starting materials, the use of water as reaction media, simple and efficient one-pot operation, and avoiding the need for any hazardous or expensive catalysts. [GRAPHICS] .
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