Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract

Automated summary

This study presents a modified methodology for the synthesis of oxadiazoles linked to amides under mild conditions, utilizing NMI-TfCl. The developed protocol has shown effectiveness and tolerance for the amide bond formation reaction of challenging amines. Additionally, the antioxidant potential of the newly synthesized compounds has been evaluated in the later stage.