Oncogenic signaling of RTK fusions becomes more granular

A spectrum of cancers arises from chromosomal translocations that fuse receptor tyrosine kinase domains to oligomerization domains from unrelated proteins. Tulpule et al. (2021) demonstrate that fusion proteins with the ability to assemble higher-order cytoplasmic protein granules can activate RAS signaling in a lipid membrane-independent manner.

Automated summary

Chromosomal translocations can generate fusion proteins that assemble cytoplasmic protein granules, leading to RAS signaling activation independent of lipid membranes.