4.6 Article

Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

Michael J. Giffin et al.

Summary: AMG 757, a bispecific T-cell engager targeting DLL3, demonstrated potent antitumor activity in SCLC models, activating T cells and inducing significant tumor regression. It showed good tolerability in nonhuman primates and has the potential for intermittent administration in patients, suggesting it as a promising option for targeting DLL3-expressing SCLC tumors in clinical settings.

CLINICAL CANCER RESEARCH (2021)

Article Immunology

Pasotuxizumab, a BiTE® immune therapy for castration-resistant prostate cancer: Phase I, dose-escalation study findings

Horst-Dieter Hummel et al.

Summary: The study reported the results of a first-in-human study of pasotuxizumab in patients with advanced castration-resistant prostate cancer. The data showed significant PSA response in some patients, suggesting the potential efficacy of this therapy in treating solid tumors.

IMMUNOTHERAPY (2021)

Article Oncology

Preclinical Assessment of AMG 596, a Bispecific T-cell Engager (BiTE) Immunotherapy Targeting the Tumor-specific Antigen EGFRvIII

Alexander Sternjak et al.

Summary: AMG 596 is a potential drug for GBM treatment with highly specific and potent T-cell activation capabilities, increasing survival rate in mice and showing promising preclinical efficacy.

MOLECULAR CANCER THERAPEUTICS (2021)

Article Oncology

Characterization of a Novel FLT3 BITE Molecule for the Treatment of Acute Myeloid Leukemia

Bettina Brauchle et al.

MOLECULAR CANCER THERAPEUTICS (2020)

Article Medicine, General & Internal

Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer

T. Andre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

How we treat metastatic colorectal cancer

Vincenzo De Falco et al.

ESMO OPEN (2019)

Article Biochemistry & Molecular Biology

Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro

Ling Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability

Frederick W. Jacobsen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Oncology

Recent advances of bispecific antibodies in solid tumors

Shengnan Yu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)

Review Immunology

Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer

Jos P. M. van Putten et al.

JOURNAL OF INNATE IMMUNITY (2017)

Article Medicine, Research & Experimental

Alterations of the apical junctional complex and actin cytoskeleton and their role in colorectal cancer progression

Adriana Sartorio Gehren et al.

TISSUE BARRIERS (2015)

Editorial Material Genetics & Heredity

The Genotype-Tissue Expression (GTEx) project

John Lonsdale et al.

NATURE GENETICS (2013)

Article Pharmacology & Pharmacy

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Dhaval K. Shah et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2012)

Review Chemistry, Multidisciplinary

Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment

Danila Coradini et al.

ACTA PHARMACOLOGICA SINICA (2011)

Review Endocrinology & Metabolism

Transmembrane mucins as novel therapeutic targets

Pamela E. Constantinou et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2011)

Review Oncology

Mucins in cancer: function, prognosis and therapy

Donald W. Kufe

NATURE REVIEWS CANCER (2009)

Article Biotechnology & Applied Microbiology

From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice

Aya Jakobovits et al.

NATURE BIOTECHNOLOGY (2007)

Article Biochemistry & Molecular Biology

Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3

P Laidler et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)

Review Oncology

Mucins in cancer: Protection and control of the cell surface

MA Hollingsworth et al.

NATURE REVIEWS CANCER (2004)