期刊
MOLECULAR CANCER RESEARCH
卷 19, 期 12, 页码 2096-2109出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-21-0009
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资金
- Canadian Institute of Health Research (CIHR) [PJT-148663]
- Cancer Research Society grant
- Natural Sciences and Engineering Research Council (NSERC)
- CIHR grant [PJT-148915]
- CIHR (CGS-M)
- NSERC (CGSD-3)
- NSERC
Inflammation-induced monocyte-derived macrophages (MoDM) and hepatocyte growth factor (HGF) have been found to increase the formation of early micrometastatic lesions in the lung, enhancing the survival rate of tumor cells.
A rate-limiting step for circulating tumor cells to colonize distant organ sites is their ability to locate a microenvironmental niche that supports their survival and growth. This can be achieved by features intrinsic to the tumor cells and/or by the conditioning of a premetastatic niche. To determine if pulmo-nary inflammation promotes the latter, we initiated models for inflammatory asthma, hypersensitivity pneumonitis, or bleomycin-induced sterile inflammation before introducing tumor cells with low metastatic potential into the circulation. All types of inflammation increased the end-stage metastatic burden of the lungs 14 days after tumor cell inoculation without overtly affecting tumor extravasation. Instead, the number and size of early micrometastatic lesions found within the interstitial tissues 96 hours after tumor cell inoculation were increased in the inflamed lungs, coincident with increased tumor cell survival and the presence of nearby inflammation-induced monocyte-derived macrophages (MoDM; CD11b thorn CD11c thorn ). Remarkably, the adoptive transfer of these MoDM was sufficient to increase lung metastasis in the absence of inflammation. These inflam-mation-induced MoDM secrete a number of growth factors and cytokines, one of which is hepatocyte growth factor (HGF), that augmented tumor cell survival under conditions of stress in vitro. Importantly, blocking HGF signaling with the cMET inhibitor capmatinib abolished inflammation-induced early micrometastatic lesion formation in vivo. These findings indicate that inflammation-induced MoDM and HGF in particular increase the efficiency of early metastatic colonization in the lung by locally preconditioning the microenvironment.
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