4.8 Article

Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila

期刊

MOLECULAR BIOLOGY AND EVOLUTION
卷 38, 期 11, 页码 4977-4986

出版社

OXFORD UNIV PRESS
DOI: 10.1093/molbev/msab221

关键词

satellite DNA; chromocenter; hybrid incompatibility; speciation

资金

  1. Howard Hughes Medical Institute
  2. American Heart Association Postdoctoral Fellowship [17POST33660746]

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The inefficient clustering of divergent satellite DNA in Drosophila hybrid cells leads to chromocenter disruption, micronuclei formation, and tissue atrophy, which is linked to the reproductive isolation between closely related species.
Although rapid evolution of pericentromeric satellite DNA repeats is theorized to promote hybrid incompatibility (HI) (Yunis and Yasmineh 1971; Henikoff et al. 2001; Ferree and Barbash 2009; Sawamura 2012; Jagannathan and Yamashita 2017), how divergent repeats affect hybrid cells remains poorly understood. Recently, we demonstrated that sequence-specific DNA-binding proteins cluster satellite DNA from multiple chromosomes into chromocenters, thereby bundling chromosomes to maintain the entire genome in a single nucleus (Jagannathan et al. 2018, 2019). Here, we show that ineffective clustering of divergent satellite DNA in the cells of Drosophila hybrids results in chromocenter disruption, associated micronuclei formation, and tissue atrophy. We further demonstrate that previously identified HI factors trigger chromocenter disruption and micronuclei in hybrids, linking their function to a conserved cellular process. Together, we propose a unifying framework that explains how the widely observed satellite DNA divergence between closely related species can cause reproductive isolation.

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