4.8 Article

Little Evidence the Standard Genetic Code Is Optimized for Resource Conservation

期刊

MOLECULAR BIOLOGY AND EVOLUTION
卷 38, 期 11, 页码 5127-5133

出版社

OXFORD UNIV PRESS
DOI: 10.1093/molbev/msab236

关键词

translation; standard genetic code; evolutionary design principles

资金

  1. Swiss National Science Foundation [PP00P3_170604]
  2. Swiss National Science Foundation (SNF) [PP00P3_170604] Funding Source: Swiss National Science Foundation (SNF)

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This paper discusses the controversy about whether the genetic code is optimized for resource conservation, with the authors arguing that the standard genetic code is not optimized for resource conservation.
Selection for resource conservation can shape the coding sequences of organisms living in nutrient-limited environments. Recently, it was proposed that selection for resource conservation, specifically for nitrogen and carbon content, has also shaped the structure of the standard genetic code, such that the missense mutations the code allows tend to cause small increases in the number of nitrogen and carbon atoms in amino acids. Moreover, it was proposed that this optimization is not confounded by known optimizations of the standard genetic code, such as for polar requirement or hydropathy. We challenge these claims. We show the proposed optimization for nitrogen conservation is highly sensitive to choice of null model and the proposed optimization for carbon conservation is confounded by the known conservative nature of the standard genetic code with respect to the molecular volume of amino acids. There is therefore little evidence the standard genetic code is optimized for resource conservation. We discuss our findings in the context of null models of the standard genetic code.

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