期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 530, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2021.111287
关键词
Adrenal cortex; Aldosterone; Zona glomerulosa; Zona fasciculata; Adherent junction; Rosette; Zonal transdifferentiation; Epithelial remodeling; Morphogenesis; FGFR2; Calcium signaling; Optopatch; GCaMP3; Cyp11b2
资金
- NIH [DK-123694, HL36977, HL-138241]
- AHA [18TPA34230077]
This article reviews the morphological features of the adrenal zona glomerulosa (zG) and recent cellular and molecular discoveries governing its formation, highlighting the organization of zG cells into rosettes and their impact on adrenal function. It discusses how rosettes arise through constriction at common cellular contact points and the role of adherens junctions in this process, as well as the invagination and folding of flat sheet-like domains in the nascent zG that give rise to compact round glomeruli in the adult zG.
How morphology informs function is a fundamental biological question. Here, we review the morphological features of the adrenal zona glomerulosa (zG), highlighting recent cellular and molecular discoveries that govern its formation. The zG consists of glomeruli enwrapped in a Laminin-beta 1-enriched basement membrane (BM). Within each glomerulus, zG cells are organized as rosettes, a multicellular structure widely used throughout development to mediate epithelial remodeling, but not often found in healthy adult tissues. Rosettes arise by constriction at a common cellular contact point mediated/facilitated by adherens junctions (AJs). In mice, small, dispersed AJs first appear postnatally and enrich along the entire cell-cell contact around 10 days after birth. Subsequently, these AJ-rich contacts contract, allowing rosettes to form. Concurrently, flat sheet-like domains in the nascent zG, undergo invagination and folding, gradually giving rise to the compact round glomeruli that comprise the adult zG. How these structures impact adrenal function is discussed.
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