期刊
MITOCHONDRION
卷 59, 期 -, 页码 76-82出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2021.04.011
关键词
Mitochondria; N-methyl-D-aspartate; Calcium; Bioenergetics; Respiration; ATP
The research findings indicate that NMDA(m) activation modulates mitochondrial bioenergetics through both Ca2+-dependent and Ca2+-independent mechanisms.
Our laboratory has demonstrated that functional N-methyl-D-aspartate-like receptors are present on neuronal mitochondria (NMDA(m)). This novel site gates the influx of Ca2+ and causes a several-fold increase in ATP levels. Although elevations in ATP in other cell types have been linked to increases in mitochondrial Ca2+, it has not been established whether the same holds true for calcium uptake via NMDA(m). In this study, we have investigated the effect of NMDA(m) activation on a variety of bioenergetic parameters. Our findings suggest that mitochondrial bioenergetics are not only modulated by NMDA(m) activation in a Ca2+-dependent but also in a Ca2+-independent manner.
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