期刊
MICROBIAL PATHOGENESIS
卷 155, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2021.104887
关键词
Corynebacterium striatum; Adherence; Biofilm; Pili; Virulence
资金
- Plan Nacional de I+D+i 2013-2016
- Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Ciencia, Innovacion y Universidades, Spanish Network for Research in Infectious Diseases (REIPI) [D16/0016/0007, RD16/0016/0008]
- European Development Regional Fund A way to achieve Europe, Operative program Intelligent Growth 2014-2020
Corynebacterium striatum is a nosocomial pathogen capable of adhering to human epithelial cells, forming biofilms, and exhibiting virulence towards nematodes. The presence of pili encoded by the SpaDEF operon may contribute to the virulence of this bacterium in hospital environments.
Corynebacterium striatum is a nosocomial pathogen which is increasingly associated with serious infections in both immunocompetent and immunocompromised patients. However, little is known about virulence factors and mechanisms that may enhance the establishment and long-term survival of Corynebacterium striatum. in the hospital environment. In this study, we investigated the ability of 22 multidrug-resistant C. striatum clinical isolates to adhere to human epithelial cells and to produce biofilm on polystyrene plates, glass and various tracheostomy tubes. We also tested the virulence of these strains on the nematode Caenorhabditis elegans. They showed good adhesion to epithelial human cells after 180 min of infection. The 22 C. striatum were able to produce biofilms on positively and negatively charged abiotic surfaces at 37 degrees C. They were also able to infect and to kill Caenorhabditis elegans after 5 days of infection. The virulence condition was associated with the presence of SpaDEF operon encoding pili in all strains. This study provides new insights on virulence mechanisms that may contribute to the persistence of C. striatum in the hospital environment, increasing the probability of causing nosocomial infections.
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