期刊
MICROBIAL DRUG RESISTANCE
卷 28, 期 1, 页码 1-6出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2020.0289
关键词
intensive care units; carbapenemase; Klebsiella pneumoniae; multilocus sequence typing
资金
- Coordenacao de Aperfeicoamento de Pessoal de Ni'vel Superior-Brazil (CAPES) [001]
- Universidade Federal de Mato Grosso do Sul
- Conselho Nacional de Desenvolvimento Cienti'fico e Tecnologico (CNPq), Instituto Oswaldo Cruz (IOC)-Fiocruz
This study investigated the molecular epidemiology of blaKPC-encoding Klebsiella pneumoniae in three public hospitals in Brazil, revealing various resistance genes, new clone types, and the spread of K. pneumoniae among different hospitals in the same region.
This study was conducted to determine the molecular epidemiology of blaKPC-encoding Klebsiella pneumoniae recovered from three public hospitals in Brazil. Molecular investigation of blaOXA-48, blaKPC, blaNDM, blaCTX-M, blaSHV, blaTEM, blaIMP, and blaVIM resistance genes was performed in 99 K. pneumoniae isolates from inpatients of intensive care units. Antimicrobial susceptibility was determined with a Vitek-2 System, except for polymyxin B, which was evaluated by the microbroth dilution test. Clonal relatedness was established by pulsed-field gel electrophoresis and multilocus sequence typing. Screening resistance genes showed that K. pneumoniae isolates carried the blaKPC (88.9%), blaSHV (73.5%), blaTEM (72.2%), and blaCTX-M (43.9%) genes. The most frequent sequence types (STs) were ST273, ST11, ST 1298, ST13, ST2687, and ST37. We report new STs in K. pneumoniae that have not been detected previously in Brazil. K. pneumoniae belonging to the same clone is present in different hospitals in the same region, showing the spread of multidrug-resistant K. pneumoniae.
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