期刊
METABOLIC SYNDROME AND RELATED DISORDERS
卷 19, 期 9, 页码 513-523出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/met.2021.0021
关键词
malnutrition; obesity; overweight; underweight; oxidative stress; children; insulin resistance
资金
- CIS/IMSS/scholarships
- Hospital General de Zona [197 IMSS]
- Hospital Regional de Alta Especialidad de Ixtapaluca
- Universidad del Valle de Mexico Campus Texcoco
- municipality of Chiconcuac, Estado de Mexico
- CONACyT [429750]
This study found that the nutritional status of children aged 3-6 years can affect oxidative stress markers, with significantly higher levels observed in obese children. Certain markers in obese children positively correlated with body mass index and Centers for Disease Control and Prevention percentiles, while antioxidant defense showed a negative correlation.
Background: Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. Objective: To compare the influence of nutritional status on oxidative stress (OS) markers in children aged 3-6 years. Methods: Children were categorized into four groups: underweight, normal weight, overweight, and obesity. Glucose (Glu), cholesterol (Chol), high-density lipoproteins, insulin, triacylglycerols (TG), triacylglycerols/glucose (TyG) index, and the homeostasis model assessment of insulin resistance (HOMA-IR) were analyzed. In addition, OS [malondialdehyde (MDA) and 3-nitrotyrosine (3-NT)] and antioxidant defense markers [superoxide dismutase (SOD), catalase (CAT), and the ratio of reduced/oxidized glutathione (GSH/GSSG)] were quantified. Results: Children with obesity showed significantly higher levels of MDA and 3-NT, and increased SOD activity compared with normal weight children. Glu, Chol, TG levels, TyG indexes, HOMA-IR, MDA, 3-NT, and SOD positively correlated with body mass index (BMI) and Centers for Disease Control and Prevention percentiles (CDC PC). However, CAT concentration and the GSH/GSSG ratio correlated negatively with BMI and CDC PC. In children with underweight, we found a positive correlation of TG levels and TyG indexes with BMI, whereas both markers positively correlated with BMI and CDC PC in children with overweight. MDA negatively correlated with BMI in children with underweight, while a positive association was observed in children with overweight. Finally, SOD, CAT, and GSH/GSSG negatively correlated with both BMI and CDC PC in children with overweight. Conclusions: Malnutrition, especially obesity, is associated with metabolic and OS disturbances in preschool children. It is urgent to design strategies to prevent malnutrition in this age group since this stage of development is crucial to potentially avoid future co-morbidities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据